By Paul Willner (auth.), Alan A. Boulton, Glen B. Baker, Mathew T. Martin-Iverson (eds.)
The Animal versions in Psychiatry volumes are loosely geared up through topic. the 1st quantity encompasses a variety of chapters curious about schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and different d- orders that could contain dopamine, akin to realization deficit sickness and mania. the second one quantity bargains with affective and nervousness issues, but additionally comprises chapters on topics now not simply categorized as both psychotic, or affective, or an- ety-related, reminiscent of aggression, psychological retardation, and reminiscence problems. 4 chapters on animal types of schizophrenia or psychoses are integrated within the current v- ume as a result significance of those issues in p- chiatry. Likewise, 3 chapters within the next quantity care for melancholy. the 1st of the 2 volumes starts with an introd- tion by means of Paul Willner reviewing the factors for assessing the validity of animal versions in psychiatry. He has written - tensively in this topic, and his thorough description of the problems of varied sorts of validity presents a framework during which to judge the following chapters. As could be obvious, the remainder chapters in either volumes will refer often to those matters. the second one bankruptcy, via Melvin Lyon, describes lots of varied methods which have been p- posed as strength animal versions of schizophrenia. it is a departure from the standard layout, inclusive of distinctive - scriptions of particular models.
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Extra info for Animal Models in Psychiatry, I
4,125-142. Jesberger J. A. and Richardson J. S. (1985) Animal models of depression: Parallels and correlates to severe depression in humans. Biol. Psychiatr. 20‘764-786. , and Satoh S. (1981) Effects of antidepressants in the rat forced swim test. Eur. J Pharmacol. 72,145-152. Lader M. ), Cambridge University Press, Cambridge, pp. 76-88. McKinney W. T. and Bunney W. E. (1969) Animal model of depression: Review of evidence and implications for research. Arch. Gen. Psychiat. 21,240-248. Miller W.
Biol. Psychiat. 10,677-690. Assessing Animal Models 23 Willner P. (1989a) Animal models of depression: An overview. Pharmacol. Thfx 45,425-455. Willner P. (1989b) Sensitization to the actions of antidepressant drugs, in Psychoactive Drugs: Tolerance and Sensitization (Emmett-Oglesby, M. W. and Goudie A. ), Humana, Clifton, NJ, pp. 407-459. ), Cambridge University Press,Cambridge, UK, pp. 3-18. , and Sampson D. (1991)Dopamine, depression and antidepressant drugs, in The Meaolimbic Dopmine System: From Motivation to Action (Willner P.
3. Opioid-Related Models Although opioid effects have been specifically tied to manic symptoms (see Lyon’s chapter on mania), they have been less convincing as models for schizophrenic behavior until the more recent discovery of the endogenous opiates, enkephalins, and endorphins. , 1976). Then De Wied (1978,1979) suggested a number of ways in which P-endorphin peptide chains could operate as neuromodulators leading to different types of psychosis. The evidence from animal models testing this hypothesis is not yet very strong.
Animal Models in Psychiatry, I by Paul Willner (auth.), Alan A. Boulton, Glen B. Baker, Mathew T. Martin-Iverson (eds.)