Advanced electroporation techniques in biology and medicine by Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov PDF

By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov

ISBN-10: 1439819068

ISBN-13: 9781439819067

"A mirrored image of the serious research of the results of electromagnetic fields on residing tissues that has taken position over the past numerous a long time, this e-book discusses the theoretical and experimental proof and concerns the consequences of sturdy electromagnetic fields and/or electrical pulses and their significance in drugs and biology. The authors current the elemental suggestions utilized in electroporation and the complicated equipment for production of nanopores, highlighting their easy technology and scientific purposes. issues contain nano electroporation, vintage electroporaiton, experimental facts for electroporation of residing cells, and electroporation for melanoma and wound healing"--Provided by means of writer. learn more... content material: fundamentals of Electroporation actual Chemical conception of Membrane Electroporation and Electrotransfer of Biogenic brokers, E. Neumann and S. Kakorin Bioelectric influence of severe Nanosecond Pulses, K.H. Schoenbach prompted Transmembrane Voltage-Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar Electroporation: A evaluate of easy difficulties in conception and test, M.S. Markov Mechanisms of Electroporation in Lipid platforms Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova Fluorescent equipment in evaluate of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte Nanoscale Restructuring of Lipid Bilayers in Nanosecond electrical Fields, P.T. Vernier Mechanisms of Electroporation of Cells Nanopores: a special Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova version of cellphone Membrane Electroporation and Transmembrane Molecular shipping, D. Miklavcic and L. Towhidi Kinetics of Pore Formation and Disappearance within the phone in the course of Electroporation, G. Saulis the heartbeat Intensity-Duration Dependency for mobile Membrane Electroporation, D. Miklavcic, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi Mechanisms of Electroporation in Tissues Drug-Free, good Tumor Ablation through Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic phone demise Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver Gene Electrotransfer: From simple strategies to Preclinical functions, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissie Technical concerns Modeling electrical box Distribution In Vivo, N. Pavselj, A. Zupanic, and D. Miklavcic techniques of Electroporation Pulse new release and evaluate of electrical Pulse turbines for telephone and Tissue Electroporation, M. Rebersek and D. Miklavcic iteration of Ultrashort Pulses, J.F. Kolb Nanosecond Pulsed electrical box supply to organic Samples: problems and power options, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir functions of Electroporation Translation of Electroporation-Mediated DNA supply to the hospital, L.C. Heller and R. Heller scientific Electrochemotherapy: The Italian event, C.R. Rossi and L.G. Campana Tumor Blood Flow-Modifying results of Electroporation and Electrochemotherapy-Experimental facts and Implications for the treatment, T. Jarm, M. Cemazar, and G. Sersa lectrochemotherapy as a part of an Immunotherapy process within the therapy of melanoma, J. Gehl ombined electric box and Ultrasound: A Nondrug-Based technique for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O' Sullivan, and D. M. Soden mixed Modality treatment: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar Irreversible Electroporation in drugs, B. Rubinsky nutrients and Biomaterials Processing Assisted by means of Electroporation, N. Lebovka and E. Vorobiev In Vivo Electroporation: an immense damage Mechanism in electric surprise Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee Index summary: Reflecting the serious research of the consequences of electromagnetic fields on residing tissues that has taken position through the years, this name summarizes the experimental findings and theories with regards to permeabilization of biomembranes by means of pulsed electrical fields. it truly is meant commonly for biomedical and actual scientists, engineers, and clinicians. learn more...

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These results indicate that nsPEFs have significant effects on the structure of the plasma ­membrane, but under certain conditions the structural changes are reversible. The time required to return to the control state can be considered as a recovery time, presumably to allow for “repair” of the structure and function. Most importantly, when using nsPEFs, these membrane integrity dyes should not be considered to be cell death markers and Annexin-V-FITC binding may not represent a valid apoptosis marker.

It must be noted that this is a preliminary result and further experiments are required to verify these results. However, even if confirmed, the removal of cancer cells would, according to these results, require a high number of pulses and, consequently, relatively long exposure times in therapeutic applications. By utilizing effects synergistic to the wideband pulse effects, it may be possible to reduce the threshold for induced cell death, apoptosis, considerably. A promising approach, according to our latest studies, is that of pulsed heating of tissue in addition to wideband pulse exposure.

The scattered signal contains information on the dielectric properties and the geometry of the target and allows its identification through an inverse scattering method. 3D scanning allows us to obtain the dielectric profile of the tissue and to detect any abnormality in a uniform background. An “antenna,” or better, a pulse-delivery system that is used for bioelectrics applications would need to operate in the antenna’s near-field. There are several concepts for such a delivery system. These are mainly based on the use of a prolate spheroidal reflector, where the pulse is launched from one focal point and reflected into a second focal point (Baum, 2007).

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Advanced electroporation techniques in biology and medicine by Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov


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